At what lithium level can significant complications such as seizures occur?

Significant complications, including seizures, can occur at lithium levels around 2.0 mmol/l. At this concentration, lithium toxicity can manifest with various neurological symptoms because lithium's mechanism of action primarily affects the central nervous system and electrolyte balance.

Levels approaching or exceeding 2.0 mmol/l indicate severe toxicity, which can lead to additional complications such as altered mental status, tremors, and potentially life-threatening situations. The clear clinical picture at this level necessitates immediate medical intervention to prevent further complications, including seizures, which are a serious manifestation of lithium toxicity.

Lower levels, while they may still require monitoring, do not usually result in the severe neurological effects associated with higher lithium concentrations. Thus, understanding the risk associated with elevated lithium levels is crucial for managing patients on lithium therapy effectively.