What is a common symptom related to hypercalcemia affecting the bones?

Bone pain is a common symptom associated with hypercalcemia. Elevated calcium levels in the bloodstream can lead to osteoclast activation, which promotes bone resorption. This process can cause bone pain due to the ongoing bone remodeling and the potential for microfractures. Osteoclast activity increases as the body tries to maintain calcium homeostasis, resulting in discomfort and pain in bones.

Other symptoms like stiffness, weakness, and numbness may occasionally arise from complications related to hypercalcemia, but bone pain is specifically tied to the direct effects of high calcium levels on the bone tissue itself, making it a hallmark symptom in such cases.