What is a common symptom of primary biliary cirrhosis?

Primary biliary cirrhosis, now more commonly referred to as primary biliary cholangitis (PBC), is an autoimmune disease that gradually destroys the bile ducts within the liver. One of the hallmark symptoms of this condition is fatigue, which can be debilitating and is often one of the earliest manifestations reported by patients.

Jaundice, a yellowing of the skin and eyes due to the accumulation of bilirubin, can occur as the disease progresses and liver function declines. Abdominal pain may also arise due to liver enlargement or related complications.

The inclusion of all these symptoms in the correct answer underscores the multifaceted presentation of PBC. Each symptom arises from the underlying pathology of the disease, which leads to cholestasis (impaired bile flow) and eventually liver damage. Recognizing the range of symptoms is crucial for early diagnosis and management of the condition.