What is the main side effect of vincristine?

Vincristine is a chemotherapeutic agent that belongs to the class of vinca alkaloids, known for its ability to inhibit cell division. One of the key side effects associated with vincristine is peripheral neuropathy, which arises due to the drug's neurotoxic effects. This condition manifests as numbness, tingling, or pain in the hands and feet, as well as weakness and loss of reflexes. The peripheral nerves are particularly sensitive to vincristine, resulting in these neurological symptoms.

The mechanism by which vincristine causes peripheral neuropathy is linked to its interference with microtubule formation, which is crucial for the normal functioning and repair of nerve cells. As a result, patients undergoing vincristine treatment must be closely monitored for these neurological effects, and dosage adjustments may be necessary if symptoms become severe.

Understanding this side effect is critical for healthcare professionals as they manage patients receiving vincristine and aim to balance effective cancer treatment with the potential for adverse effects.