What laboratory tests are essential to investigate for biliary obstruction in PBC?

The essential laboratory tests to investigate for biliary obstruction in Primary Biliary Cholangitis (PBC) include imaging studies such as abdominal ultrasound, CT, and MRI. These modalities are crucial in assessing the biliary tree and liver structure.

An abdominal ultrasound is often the first-line imaging choice due to its non-invasive nature and ability to detect bile duct dilation, masses, or any other abnormalities indicative of obstruction. A CT scan provides a more detailed view and can help visualize the surrounding structures, while MRI may be utilized to get a clearer image of the biliary and vascular anatomy without exposure to radiation.

In the context of biliary obstruction related to PBC, these imaging techniques provide insights that are essential for diagnosis, guiding further management or intervention if needed. Therefore, they are key in the investigation process.