Which mutation is responsible for MEN1 syndrome?

The mutation responsible for MEN1 syndrome is located on chromosome 11. MEN1, or Multiple Endocrine Neoplasia type 1, is a hereditary condition characterized by the development of tumors in multiple endocrine glands, such as the pituitary gland, pancreas, and parathyroid glands. The gene involved in MEN1 is the MEN1 gene, which is located at 11q13. This gene encodes a protein known as menin, which is crucial for regulating cell growth and division.

Mutations in the MEN1 gene lead to the dysregulation of these processes, contributing to the development of endocrine tumors associated with MEN1 syndrome. Understanding the genetic basis of this condition is vital for early diagnosis and management, as well as for family planning and genetic counseling.

The other chromosomes listed do not contain the MEN1 gene and are not associated with MEN1 syndrome. This distinguishes chromosome 11 as the specific location of the mutation responsible for this condition.