Do NSAIDs maintain patency of the ductus arteriosus?

The ductus arteriosus (DA) is a key blood vessel that connects the pulmonary artery and the descending aorta in a fetus, allowing blood to bypass the non-functioning lungs. This vessel naturally closes after birth as part of the transition to breathing air. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as indomethacin or ibuprofen, are actually used to promote the closure of the ductus arteriosus rather than maintain its patency.

In certain clinical situations, such as in premature infants, maintaining patency of the ductus arteriosus can be crucial for adequate blood circulation and to ensure that the blood can bypass the lungs. However, the role of NSAIDs counteracts this need by promoting closure, particularly in cases where a patent ductus arteriosus (PDA) leads to complications.

Therefore, stating that NSAIDs maintain patency is incorrect, as their pharmacological action leads to the opposite effect. This is why the assertion that NSAIDs maintain the patency of the ductus arteriosus is false.