HPV types 16 and 18 are most commonly linked to which disease?

HPV types 16 and 18 are high-risk strains that have been conclusively linked to cervical cancer. This association stems from their ability to integrate into host DNA and produce proteins that can disrupt normal cellular control mechanisms, leading to malignant transformation. The oncogenic potential of these particular HPV types is well-documented, and they are responsible for the majority of cervical cancer cases globally.

While HPV can also be involved in other diseases, such as genital warts (which are typically caused by low-risk types), skin cancer, and oral cancers, types 16 and 18 are specifically recognized for their strong connection to cervical carcinogenesis. The understanding of the role these strains play in the progression to cervical cancer has significantly influenced public health initiatives, including vaccination programs aimed at reducing the incidence of this disease.