If serum transaminases are raised but not exceeding the limit, what is the recommended action?

When serum transaminases are elevated but do not exceed the established limits, the recommended action is to repeat liver function tests (LFTs) in 6 weeks while continuing the medication. This approach allows healthcare providers to monitor transaminase levels over time to determine if the elevation is persistent or if it resolves on its own.

Continuing the medication while monitoring liver function is appropriate because transient elevations in liver enzymes can occur for various reasons that are not necessarily related to medication toxicity. By waiting and re-evaluating the levels, clinicians can ascertain the significance of the elevation, ensuring that patients are not prematurely taken off beneficial medications without clear evidence of harm.

If the levels were to rise significantly or if the patient developed symptoms suggestive of liver dysfunction, then further evaluation or intervention might be warranted. Overall, this approach balances patient safety with the need for effective management of their underlying condition, typically hyperlipidemia when statins are involved.