What contraindicates the use of Zanamivir?

Zanamivir, an antiviral medication used for the treatment of influenza, is contraindicated in individuals with asthma due to the risk of bronchospasm. Inhalation of Zanamivir can cause airway irritation, which may provoke respiratory symptoms in patients with underlying asthma. This risk is particularly concerning because asthmatic patients already have heightened airway hyperreactivity. Therefore, using Zanamivir in these patients could potentially exacerbate their condition and lead to severe respiratory complications.

The other options do not present the same level of contraindication with Zanamivir. Chronic obstructive pulmonary disease might raise some concerns, but it is not an absolute contraindication as some patients with COPD may still benefit from the medication. A history of heart disease isn't specific to Zanamivir's mechanisms or side effects, so it typically does not exclude its use. Recent vaccination for influenza would not contraindicate the use of Zanamivir, as vaccination and antiviral treatment can occur simultaneously, with no adverse interactions between the two.