What fetal complication is associated with aspirin use during pregnancy?

Aspirin use during pregnancy has been studied for its potential risks and benefits, particularly regarding its effects on the fetus. Kernicterus, a severe form of jaundice that can lead to brain damage, is associated with the use of high-dose aspirin in late pregnancy. High doses of aspirin may interfere with the baby's ability to metabolize bilirubin, leading to bilirubin accumulation and, consequently, kernicterus.

While it’s important to note that low-dose aspirin is often prescribed during pregnancy for specific conditions like preventing preeclampsia and is generally considered safe, the risk of higher doses must be managed carefully due to complications such as kernicterus.

The other conditions listed, such as neural tube defects and congenital heart defects, are more commonly associated with other factors, including maternal folic acid deficiency or genetic predispositions, rather than with aspirin use specifically. Limb abnormalities are also primarily related to specific teratogens or genetic conditions rather than aspirin. Therefore, understanding the specific risks associated with aspirin is crucial for safe prescribing during pregnancy.