What genetic inheritance pattern is associated with all MEN2 syndromes?

The genetic inheritance pattern associated with all MEN2 syndromes is autosomal dominant. This means that only one copy of the mutated gene inherited from an affected parent is necessary for an individual to develop the syndrome.

MEN2 syndromes, including Multiple Endocrine Neoplasia type 2A (MEN2A) and type 2B (MEN2B), are primarily linked to mutations in the RET proto-oncogene. Because the gene is located on an autosome (a non-sex chromosome), the dominant inheritance means that both males and females have an equal chance of being affected.

Familial transmission of MEN2 indicates that the presence of the mutation in one parent can lead to the development of the syndrome in children, regardless of whether they inherit the disorder from their maternal or paternal lineage. This pattern of inheritance explains why family history is a significant aspect of assessing risk for these syndromes.

Other inheritance patterns such as autosomal recessive, X-linked recessive, and mitochondrial inheritance do not apply to MEN2 syndromes. Autosomal recessive conditions require both parents to be carriers for a child to express the condition, which is not the case with MEN2. X-linked recessive inheritance mainly affects males, as females would require two