What is a notable consequence of C2 deficiency?

C2 deficiency is associated with a higher susceptibility to infections, particularly bacterial infections, due to its role in the complement system, which is essential for opsonization and clearance of bacteria. The complement system helps to identify pathogens and marks them for destruction by phagocytes. A deficiency in C2 means that this key part of the immune response is compromised, reducing the ability to effectively target and eliminate bacterial pathogens.

In addition to promoting bacterial infections, C2 also plays a part in the clearance of immune complexes and apoptotic cells. When the complement system is not functioning optimally due to C2 deficiency, this can lead to complications such as systemic lupus erythematosus. However, the most direct and notable consequence of C2 deficiency is the increased susceptibility to bacterial infections, as the body's primary defense mechanism against these pathogens is impaired.

This focus on bacterial infections is critical, as opposed to the other potential consequences related to allergic reactions, viral infections, and autoimmune diseases which may not have a direct and notable link to C2 deficiency compared to the heightened risk of bacterial infections.