What is a potential side effect of thiazide diuretics in pregnancy related to blood components?

Thiazide diuretics, which are often used to manage hypertension and fluid retention, can influence blood components, notably in the context of pregnancy. One potential side effect is neonatal thrombocytopenia, which refers to a reduced platelet count in the newborn. This condition can arise due to the effects of the medication crossing the placenta and disrupting normal platelet production or function.

The mechanism behind this can involve various factors, including the alteration in maternal and fetal hemostatic balance caused by thiazide diuretics. While the direct impact on platelet count may not be extensively researched, the association of thiazide diuretics with platelet-related issues is recognized. Therefore, monitoring both the mother and the neonate for changes in blood components is prudent when thiazide diuretics are used during pregnancy.

Other options, while indicative of various potential issues, do not specifically align with the known effects of thiazide diuretics on blood components. Neonatal goitre and hypoglycaemia are more commonly associated with other medications or conditions during pregnancy, while electrolyte disturbances, though possible due to diuretics, do not pinpoint the direct effect on blood components like thrombocytopenia does. Thus, neonatal thrombocytopenia emerges as a significant