What is often noted in histology for patients with Crohn's disease?

Fissuring ulcers are a characteristic finding in the histological examination of Crohn's disease. This inflammatory bowel disease is known for causing transmural inflammation, which can lead to ulceration that penetrates deeply into the intestinal wall. The fissuring or linear ulcers often occur in areas where the bowel wall is particularly affected and reflect the episodic nature of the inflammation in Crohn's disease.

These ulcers can contribute to complications such as strictures or fistulas, which are common in Crohn's disease due to the unique pattern of inflammation that is not limited to the mucosal surface but involves all layers of the bowel. This finding helps differentiate Crohn's disease from other similar conditions that may not exhibit the same degree of ulceration or depth of inflammation.

In contrast, the absence of inflammation, proliferation of goblet cells, and mucosal atrophy do not typically characterize Crohn's disease. Instead, these features might be associated with other gastrointestinal disorders or stage of chronic disease, but they do not represent the hallmark histological findings of Crohn's disease.