What is the first-line management for uncomplicated gonorrhea?

The first-line management for uncomplicated gonorrhea is typically based on the guidelines that recommend the use of a cephalosporin, particularly ceftriaxone, in conjunction with azithromycin. This combination therapy is important for effectively treating the infection and addressing potential antibiotic resistance.

In recent years, guidelines have shifted towards using cephalosporins as they are more effective against Neisseria gonorrhoeae, the bacteria that causes gonorrhea. Azithromycin is often included in the regimen to provide dual therapy, which helps prevent treatment failures and the emergence of resistant strains of the bacteria.

Other options like ciprofloxacin, doxycycline, or azithromycin alone are not preferred as first-line treatments. Ciprofloxacin, a fluoroquinolone, has seen rising resistance, making it less effective. Doxycycline is typically not used as a standalone treatment for gonorrhea, and azithromycin without the cephalosporin may not provide comprehensive coverage necessary due to potential resistance mechanisms.

Therefore, the use of cephalosporins is the most effective option for first-line treatment of uncomplicated gonorrhea, ensuring that healthcare providers can address the infection robustly and mitigate rising resistance issues.