What is the primary difference between Berger's disease and post-streptococcal glomerulonephritis?

The primary distinction between Berger's disease (IgA nephropathy) and post-streptococcal glomerulonephritis lies in their clinical presentations and the timing of their symptoms in relation to infections.

Berger's disease typically manifests with hematuria, often following a viral upper respiratory tract infection (URTI), but it can present at various times, including weeks or months after the infection. The timing is less immediate compared to post-streptococcal glomerulonephritis.

On the other hand, post-streptococcal glomerulonephritis, which is a consequence of an immune response to group A streptococcal infections, tends to occur within a more defined timeframe, generally 1-2 weeks following the infection.

Thus, the assertion that Berger's disease presents 1-2 days after an URTI is accurate and serves to highlight how its onset is related to preceding infections. This differentiates it from post-streptococcal glomerulonephritis, which has a different temporal relationship with infectious events.