What is the primary treatment for Weil's disease?

The primary treatment for Weil's disease, which is a severe form of leptospirosis, typically involves the use of intravenous antibiotics, such as penicillin or amoxicillin. The rationale for choosing intravenous antibiotics is rooted in the need for prompt and effective management of a potentially life-threatening condition. Weil's disease can lead to serious complications, including liver failure, renal impairment, and hemorrhagic manifestations. Therefore, the use of intravenous antibiotics ensures high bioavailability and rapid therapeutic effect, which is crucial for controlling the infection caused by the Leptospira bacteria.

Supportive care plays a vital role in managing the symptoms and complications of the disease, but it does not address the underlying infection directly. Other treatments, such as oral rehydration therapy, are helpful to manage fluid balance but are not sufficient as primary interventions. While oral antibiotics may be suitable for mild cases of leptospirosis, they are not the first-line treatment for severe presentations like Weil's disease. The use of IV antibiotics helps prevent the progression of the disease and the risk of serious outcomes.