What is the recommended frequency for surveillance colonoscopy in individuals with Lynch syndrome?

The recommended frequency for surveillance colonoscopy in individuals with Lynch syndrome is every 1.5 to 2 years starting at age 25. This recommendation is based on the increased risk of colorectal cancer associated with Lynch syndrome, which is a hereditary condition caused by inherited mutations in DNA mismatch repair genes.

Surveillance colonoscopy in Lynch syndrome is crucial for early detection and prevention of cancer because these individuals have a significantly higher lifetime risk of developing colorectal cancer compared to the general population. The suggested frequency allows for vigilant monitoring while balancing the risks of intervening too frequently, such as the potential for unnecessary procedures or complications.

Colonoscopy performed every 1.5 to 2 years aligns with clinical guidelines, which prioritize early intervention and timely treatment if polyps or cancerous lesions are detected. This proactive approach is essential given the aggressive nature of cancers that may develop due to the underlying genetic predisposition present in individuals with Lynch syndrome.