What procedure can be performed at 12 weeks gestation to investigate sickle cell anemia?

At 12 weeks gestation, chorionic villus sampling (CVS) is the appropriate procedure to investigate sickle cell anemia. This diagnostic test involves taking a small sample of the placental tissue, which contains fetal genetic material. CVS can be conducted as early as 10-13 weeks of gestation, making it suitable for early genetic testing.

The primary advantage of CVS is that it can provide results earlier in the pregnancy compared to other procedures, such as amniocentesis, which is typically performed later, around 15-20 weeks of gestation. By performing CVS at 12 weeks, healthcare providers can make timely decisions regarding the management of conditions such as sickle cell anemia, allowing for greater options for prenatal care and planning.

While the triple test is a screening tool for certain chromosomal abnormalities and fetal markers, it does not provide definitive information on genetic conditions like sickle cell anemia. Similarly, ultrasounds are important for monitoring the development of the fetus but do not diagnose genetic disorders. Amniocentesis, though it can test for sickle cell anemia, is not performed until a later stage in pregnancy. Therefore, chorionic villus sampling stands out as the most appropriate and timely option for investigating this condition at