Which drug is most commonly associated with drug-induced lupus?

The drug most commonly associated with drug-induced lupus is procainamide. This condition, known as drug-induced lupus erythematosus (DILE), can occur when certain medications cause an autoimmune response that mimics systemic lupus erythematosus (SLE). Procainamide, an antiarrhythmic medication, has been well-documented to induce lupus-like symptoms in some patients due to its effects on the immune system.

Hydralazine and isoniazid are also known to be associated with drug-induced lupus, but the association is less prevalent compared to procainamide. While hydralazine is commonly linked to this condition, especially in individuals with slow acetylator phenotypes, procainamide remains the most classic example. Aspirin, on the other hand, is not associated with drug-induced lupus as it does not typically induce autoimmune responses related to lupus. Therefore, procainamide stands out as the drug most frequently connected to drug-induced lupus.