Which medication is known to potentially cause a gout flare-up?

Pyrazinamide is recognized for its association with the development of gout flare-ups due to its effect on uric acid metabolism. It is primarily used as a part of the combination therapy for tuberculosis. Pyrazinamide can inhibit the renal excretion of uric acid, leading to increased levels of uric acid in the bloodstream (hyperuricemia), which is a significant risk factor for gout. When uric acid levels exceed a certain threshold, it can crystallize in the joints, potentially triggering an acute inflammatory response characteristic of a gout attack.

In contrast, the other medications listed are less commonly associated with gout flare-ups. Beclometasone is a corticosteroid primarily used for its anti-inflammatory effects and does not typically raise uric acid levels. Trastuzumab is a monoclonal antibody used in cancer treatment, with no direct effect on uric acid levels. Zollinger-Ellison medication, which is used to manage gastric acid secretion, is also not known to influence uric acid metabolism significantly.