Which of the following can indicate possible chronic Hepatitis B infection?

The indication of a possible chronic Hepatitis B infection is primarily established through the combination of specific serological markers. In this case, the presence of HBV DNA alongside HBeAg is significant.

HBeAg (Hepatitis B e antigen) typically suggests active viral replication and is a marker of infectivity. When HBV DNA is detected in conjunction with HBeAg, it indicates that the virus is actively replicating, which suggests that the individual has a chronic infection rather than an acute one. Chronic Hepatitis B often presents with the persistence of HBsAg over six months, the presence of HBV DNA, and potentially HBeAg positivity.

This combination reflects the ongoing activity of the virus in the liver, raising the likelihood of chronic infection. In contrast, the other options do not provide definitive evidence of a chronic Hepatitis B infection due to reasons such as indicating acute infection or immune response rather than continuous viral activity.