Which of the following conditions tends to deteriorate during pregnancy?

Systemic Lupus Erythematosus (SLE) is an autoimmune condition that can indeed deteriorate during pregnancy. This occurs due to the complexities of the immune system's response when a pregnant person carries a fetus, which is genetically distinct from them. The hormonal and physiological changes during pregnancy can exacerbate SLE, leading to an increased risk of flares, particularly in the late second and third trimesters. Women with a history of severe SLE before pregnancy are especially at higher risk for complications, including organ damage and adverse pregnancy outcomes.

In contrast, other conditions listed may behave differently during pregnancy. Asthma can often remain stable or even improve due to hormonal changes but does require careful monitoring. Allergies may fluctuate—some may worsen, while others might not change significantly. Hypothyroidism typically requires careful management, but it does not inherently worsen with pregnancy if appropriately treated. Understanding these dynamics helps healthcare providers manage the needs of pregnant individuals with these conditions effectively.