Which of the following conditions might require monitoring with APTT?

Monitoring with Activated Partial Thromboplastin Time (APTT) is particularly relevant in the context of hemophilia, a bleeding disorder characterized by a deficiency in one of the clotting factors necessary for blood coagulation. APTT is used to evaluate the intrinsic pathway of coagulation, which is often affected in patients with hemophilia, making it crucial for assessing the efficacy of treatment and the risk of bleeding events.

In hemophilia, the monitoring of APTT can guide treatment decisions, especially when patients are administered factor replacement therapy. Regular assessments using APTT help to ensure that the levels of clotting factors are appropriate to prevent excessive bleeding during surgeries or after injuries.

The other options—thrombocytopenia, hypertension, and diabetes mellitus—do not typically require monitoring with APTT. Thrombocytopenia is monitored with platelet counts rather than APTT, hypertension is managed through blood pressure measurements, and diabetes mellitus is monitored using glucose levels rather than APTT. Therefore, using APTT monitoring is specifically essential for hemophilia to manage and treat the condition effectively.