Which of the following is a potential complication of multiple myeloma?

Hypercalcemia is a well-known potential complication of multiple myeloma due to the pathological nature of the disease. Multiple myeloma leads to an overproduction of monoclonal antibodies and the activation of osteoclasts, which results in bone resorption and the release of calcium into the bloodstream. This release can significantly elevate serum calcium levels, leading to hypercalcemia. Symptoms of hypercalcemia may include fatigue, confusion, nausea, and constipation, making it crucial to monitor and manage this condition in patients with multiple myeloma.

The other options do not typically relate to multiple myeloma. Hypoglycemia is generally not a complication associated with this condition, as multiple myeloma does not significantly affect glucose metabolism in the same way that diabetes or certain types of tumors might. Acidosis can occur in a variety of clinical contexts, including respiratory issues or severe metabolic disturbances, but it is not directly linked to multiple myeloma. Thrombocytosis, which refers to an elevated platelet count, is also not a characteristic complication of multiple myeloma, where patients more commonly experience thrombocytopenia, or low platelet counts, due to bone marrow infiltration or the effects of chemotherapy.

Thus, hypercalcemia stands out as a