Which of the following is a known manifestation on the fetus from Parvovirus B19 infection?

Parvovirus B19 infection during pregnancy is particularly concerning due to its ability to affect the fetus, primarily leading to severe anemia. This occurs because Parvovirus B19 has a specific tropism for erythroid progenitor cells in the bone marrow, which are involved in red blood cell production. When the virus infects these cells, it can cause a decrease in red blood cell production, resulting in fetal anemia. This condition can manifest as hydrops fetalis, a severe fetal condition characterized by an abnormal accumulation of fluid in the fetal compartments.

Other options, while they may represent serious conditions in a developing fetus, are not typically associated with Parvovirus B19 infection. Hydrocephalus, neural tube defects, and cardiac inflammation are linked to other viral infections or congenital syndromes but are not common manifestations of Parvovirus B19. The focus of Parvovirus B19 is primarily on the hematological impact, making severe anemia the most relevant and specific consequence of this infection in fetal development.