Which syndrome is commonly associated with T cell deficiencies?

Di George Syndrome is primarily associated with T cell deficiencies due to a developmental issue during embryogenesis that affects the third and fourth pharyngeal pouches. This condition leads to the underdevelopment or absence of the thymus gland, which is crucial for the maturation of T cells. As a result, individuals with Di George Syndrome typically present with notable T cell deficiencies, increasing their susceptibility to infections.

In contrast, other syndromes listed in the options do have some implications for T cell function, but they also involve additional immunological parameters. For example, Wiskott-Aldrich Syndrome is associated with a triad of symptoms, including eczema, thrombocytopenia, and immunodeficiency, which affects both B and T cell functions, but it does not primarily stem from a lack of T cells alone. Severe combined immunodeficiency involves both T and B cell deficiencies due to various genetic mutations, but it is a broader category than the specific deficiencies seen in Di George Syndrome. Hyper-IgM syndrome is primarily characterized by elevated levels of IgM and a defect in class switching, which relates to B cell function rather than a direct deficiency of T cell numbers, though it can have secondary effects on T cell activity.

Thus, Di George Syndrome stands